Antidiabetic and Antioxidant potential of Methanol extract of Salix caprea inflorescence

Salix caprea is widely used in folk medicine for rheumatoid arthritis, malaria, various hemorrhages, gout, neuralgia and intestinal diseases as an antipyretic, analgesic, anti-inflammatory, antibacterial, hemostatic, sedative, and antihelminthic agent However, There are no critical reports available about anti diabetic potential of Salix caprea flowers. So anti diabetic effect of methanol extract of Salix Caprea flower (SCF) on alloxan-induced diabetic rats was studied. A single dose of 400mg/ml of the extract were orally administered as the treatment dose and the blood glucose levels blood glucose level (BGL) examined for 0, 7, 14, 21, 28 days intervals. Free radical scavenging activity was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical. The data generated were analyzed using Spss reports. The % reduction of glucose levels calculated as 35.23% -62.80% (standard drug, 10mg/ml), 30.60 46.69 (test extract, 400mg/ml) respectively. The extract exhibited significant (p<0.05and p<0.01) reduction in the blood glucose levels of the albino rats along with some other biochemical variables. The extract compared favorably with the standard reference drug (Glibenclamide) which all gave their maximum BGL reduction at 20 Day duration.